Fig 8. WORMHOLE SVMs produce an expanded set of LDOs while maintaining functional similarity relative to PANTHER LDOs.

Conservation of GO term annotation between genes in each gene pair is plotted against the number of gene pairs contained with each dataset for PANTHER (green point), all other constituent algorithms (black points), PANTHER LDOs (red points), WORMHOLE SVMs (blue lines), and WORMHOLE RBHs (cyan points). Points or lines indicate mean, and error b ars or colored regions represent 95% confidence intervals, for Schlicker similarity in GO terms between genes (see Materials and Methods).