Table 4. Gene ontology (GO) term and enzyme classification (EC) similarity for predictions by PANTHER LDOs, WORMHOLE SVMs, and WORMHOLE RBHs.

SVMs and RBHs datasets contain gene pairs with WORMHOLE Score ≥ 0.5.

Dataset	Query Species	Target Species	# LDOs	GO Term Conservation(Schlicker Similarity)		# Enzyme LDOs	EC Conservation(Schlicker Similarity)
				Mean	95% Conf.		Mean	95% Conf.
PANTHER LDOs	all	all	23600	0.497	0.0030	5934	0.988	0.0019
WORMHOLE SVMs	all	all	33865	0.486	0.0024	8132	0.977	0.0023
WORMHOLE RBHs	all	all	26082	0.497	0.0028	6521	0.984	0.0021
PANTHER LDOs	invertebrate	invertebrate	4111	0.398	0.0064	607	0.985	0.0069
WORMHOLE SVMs	invertebrate	invertebrate	5545	0.398	0.0056	836	0.977	0.0070
WORMHOLE RBHs	invertebrate	invertebrate	4569	0.399	0.0061	684	0.981	0.0069
PANTHER LDOs	vertebrate	vertebrate	8335	0.549	0.0050	2654	0.998	0.0013
WORMHOLE SVMs	vertebrate	vertebrate	9354	0.541	0.0047	2820	0.997	0.0018
WORMHOLE RBHs	vertebrate	vertebrate	8865	0.547	0.0048	2748	0.997	0.0017
PANTHER LDOs	vertebrate	invertebrate	11154	0.496	0.0043	2673	0.979	0.0037
WORMHOLE SVMs	vertebrate	invertebrate	18966	0.484	0.0032	4476	0.965	0.0037
WORMHOLE RBHs	vertebrate	invertebrate	12648	0.496	0.0040	3089	0.973	0.0039