Table 3. Comparison of maternal age-specific rates for common autosomal trisomies (trisomies 21, 18 and 13) and aneuploidies per 1,000 fetuses and live births in various age groups from various studies.
Maternal age | Fetus rate at the time of amniocentesis | Live births rate at the time of delivery | |||||
---|---|---|---|---|---|---|---|
This study | Hook 1983 [4] | Ferguson-Smith 1984 [5] | Yaegashi 1998 [6] | Park 2010 [7] | Kim 2013 [8]a | Savva 2010 [15] | |
T21, T13, T18 | T21, T13, T18 | T21, T13, T18 | T21, T13, T18 | All aneuploidies | T21, T13, T18 | T21, T18, T13 | |
34 | 4.54 | 4.30 | N/A | N/A | N/A | N/A | 1.83 |
35 | 4.61 | 5.50 | 4.50 | 3.94 | 7.92 | 11.14 | 2.22 |
36 | 5.71 | 7.10 | 5.90 | 5.13 | 10.06 | 13.15 | 2.81 |
37 | 7.84 | 8.90 | 7.70 | 6.64 | 12.79 | 15.54 | 3.64 |
38 | 11.01 | 11.50 | 10.00 | 8.6 | 16.26 | 18.35 | 4.85 |
39 | 15.22 | 14.70 | 13.20 | 11.15 | 20.67 | 21.68 | 6.53 |
40 | 20.46 | 18.80 | 17.20 | 14.45 | 26.28 | 25.62 | 8.78 |
41 | 26.73 | 24.00 | 22.50 | 18.73 | 33.41 | 30.28 | 11.67 |
42 | 34.04 | 30.60 | 29.40 | 24.31 | 42.47 | 35.80 | 15.18 |
43 | 42.39 | 39.20 | 36.00 | 31.55 | 53.99 | 42.34 | 19.18 |
44 | 51.77 | 50.30 | 40.90 | 40.96 | 68.63 | 50.08 | 23.47 |
45 | 62.19 | 64.40 | 50.60 | 53.19 | 87.25 | 59.26 | 27.79 |
46 | 73.64 | 82.5 | 62.80 | N/A | N/A | 70.13 | 31.90 |
47 | 86.14 | 105.8 | 28.6 | N/A | N/A | 83.04 | 35.65 |
48 | 99.66 | 135.6 | 28.6 | N/A | N/A | N/A | 38.91 |
Sample size | 17,819 | N/A | 52,965 | 5,484 | 2,032 | 5,055 | 4.5 million |
Study location | Thailand | Mixed | Europe | Japan | Korea | Korea | Mixed |
T21: trisomy 21, T18: trisomy 18, T13: trisomy 13, N/A: not available.
aAge at the time of delivery.