Table 2. Positive ratio of TCS, cardiac MIBG scintigraphy and olfactory function tests in the PD and APS groups.

A) Total patients (n = 139)
Combinations of test results		PD	APS	p-value	PD diagnosis
option					Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
1	SN+ (≥0.16 cm2)	34 (53.1%)	2 (8.3%)	<0.001	53.1	91.7	94.4	42.3
	MIBG+ (≤2.0)	71 (70.3%)	5 (13.2%)	<0.001	70.3	86.8	93.4	52.4
	OE+ (≤4)	59 (58.4%)	9 (23.7%)	<0.001	58.4	76.3	86.8	40.8
2	At least one positive result from 3 tests	87 (86.1%)	14 (36.8%)	<0.001	86.1	63.2	86.1	63.2
3	At least two positive results from 3 tests	60 (59.4%)	2 (5.3%)	<0.001	59.4	94.7	96.8	46.8
	(SN or MIBG) and OE	52 (51.5%)	1 (2.6%)	<0.001	51.5	97.4	98.1	43
	(OE or MIBG) and SN	29 (45.3%)	1 (4.2%)	<0.001	45.3	95.8	96.7	39.7
	(OE or SN) and MIBG	56 (55.4%)	2 (5.3%)	<0.001	55.4	94.7	96.6	44.4
4	Positive results for all 3 tests	17 (26.6%)	0 (0%)	<0.001	26.6	100	100	33.8
B) Early-stage patients (n = 40)
Combinations of test results		PD	APS	p-value	PD diagnosis
option					Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
1	SN+ (≥0.16 cm2)	12 (50.0%)	1 (6.3%)	0.004	50	93.8	92.3	55.6
	MIBG+ (≤2.0)	24 (57.1%)	3 (12.5%)	<0.001	57.1	87.5	88.9	53.8
	OE+ (≤4)	23 (54.8%)	5 (20.8%)	0.007	54.8	79.2	82.1	50
2	At least one positive result from 3 tests	32 (76.2%)	8 (33.3%)	0.001	76.2	66.7	80	61.5
3	At least two positive results from 3 tests	21 (50%)	1 (4.2%)	<0.001	50	95.8	95.5	52.3
	(SN or MIBG) and OE	20 (47.6%)	0 (0%)	<0.001	47.6	100	100	52.2
	(OE or MIBG) and SN	9 (37.5%)	1 (6.3%)	0.025	37.5	93.8	90	50
	(OE or SN) and MIBG	19 (45.2%)	1 (4.2%)	<0.001	45.2	95.8	95	51.7
4	Positive results for all 3 tests	6 (25.0%)	0 (0%)	0.03	25	100	100	47.1

SN+ = substantia nigra hyperechogenicity positive; MIBG+ = cardiac MIBG scintigraphy positive; OE+ = olfactory testing positive