Table 1. Set of standard operating procedures (SOPs) used in the NIDIAG study on persistent digestive disorders.

Number	Type	Purpose of SOP	End user	Syndrome
1	Clinical	History taking	Site investigator	Digestive
2	Clinical	Clinical examination	Site investigator	Digestive
3	Clinical	Selection of controls without digestive syndrome	Site investigator	Digestive
4	Clinical	Specific treatment procedures (including dosage)	Site investigator	Digestive
5	Clinical	Assessing inclusion and exclusion criteria	Site investigator	Digestive
6	Clinical	Patient recruitment and patient flow	Site investigator	Digestive
7	Laboratory	Kinyoun staining technique	Laboratory technician	Digestive
8	Laboratory	Modified acid-fast staining technique	Laboratory technician	Digestive
9	Laboratory	Crypto/Giardia Duo-Strip rapid diagnostic test (RDT)	Laboratory technician	Digestive
10	Laboratory	Kato-Katz thick smear technique	Laboratory technician	Digestive
11	Laboratory	Baermann funnel concentration technique	Laboratory technician	Digestive
12	Laboratory	Mini-FLOTAC technique	Laboratory technician	Digestive
13	Laboratory	How to obtain a stool sample	Laboratory technician	Digestive
14	Laboratory	Formalin-ether concentration technique	Laboratory technician	Digestive
15	Laboratory	Koga agar plate culture	Laboratory technician	Digestive
16	Laboratory	Direct fecal smear technique	Laboratory technician	Digestive
17	Laboratory	Preparation of aliquots for molecular post-hoc testing	Laboratory technician	Digestive
18	Laboratory	Urine point-of-care circulating cathodic antigen (POC-CCA) RDT for the diagnosis of Schistosoma mansoni	Laboratory technician	Digestive
19	Laboratory	Diagnostic sample flow	Laboratory technician	Digestive
20	Laboratory	Urine sampling	Laboratory technician	Digestive
21	Quality	Obtaining informed consent	Site investigator	Common
22	Quality	Numbering system to be used in NIDIAG studies	Laboratory technician	Digestive mainly
23	Quality	Management of study documents	Principal investigator (PI)/site investigator/ nurse/laboratory technician	Common
24	Quality	SOP on SOPs	SOP author	Common
25	Quality	External monitoring	PI/site investigator	Common
26	Quality	Internal quality control activities	Quality manager	Common
27	Quality	Good clinical laboratory practice (GCLP) supervision visits	Quality manager	Common
28	Quality	Min/max thermometer	Laboratory technician	Common
29	Quality	Stock management	Laboratory technician	Common
30	Quality	Handling of expired and disqualified products	Laboratory technician	Common
31	Quality	Handling and storage of rapid diagnostic tests	Laboratory technician	Digestive
32	Data	Completing case report forms (CRFs)	Site investigator	Common
33	Data	Procedure for data management	Data manager	Digestive