Table 2.

Results of univariate and multivariable Cox models using alternative approaches to represent SSRI + SNRI exposure

Models	Unadjusted HR (95 % CI)	Adjusted HR (95 % CI)
SSRI/SNRI current use—first definitiona	1.88 (1.48–2.39)	1.68 (1.32–2.15)b
SSRI/SNRI current use—second definitionc	1.58 (1.17–2.14)	1.47 (1.09–1.99)d
SSRI/SNRI stepwise	1.83 (1.35–2.47)	1.69 (1.28–2.22)e
SSRI/SNRI recent/former
Former use	1.70 (1.08–2.65)	1.42 (0.87–2.31)
Recent use	1.80 (1.34–2.42)	1.61 (1.19–2.19)f

^aSSRI/SNRI use was assumed to be constant for the period covered by each interview

^bAdjusted for Charlson score, age, sex, education level, fall in previous month, physical activity, depressive symptoms (MCS scale), BMD hip and lumbar, thiazolidinedione use, vitamin D, and previous vertebral deformity (Genant grade ≥2)

^cSSRI/SNRI use was assumed to continue during the 5-year period only if the subject reported being on these drugs both at the beginning and at the end of the period

^dAdjusted for the same variables as above, except smoking

^eAdjusted for Charlson score, age, sex, education level, fall in previous month, physical activity, depressive symptoms (MCS scale), BMD hip and lumbar, thiazolidinedione and antihypertensive use, vitamin D, and previous vertebral deformity (Genant grade ≥2)

^fAdjusted for the same variables as above, except education