Table 3.
Top 5 of up regulated proteins in original patients tumors which were successfully engrafted into NSG mice (S) compared to tumors were not successfully engrafted (F), and in comparison between PDX tumors (PDX) and original patient tumors (Original)
| S vs F (ER+HER2−) | LogFC | p-value | adj.p-value |
|---|---|---|---|
| L1CAM | 2.01 | 0.002 | 0.178 |
| PTK2 | 1.22 | 0.016 | 0.777 |
| AKT | 1.01 | 0.031 | 0.451 |
| SERPINE1 | 0.77 | 0.003 | 0.185 |
| SLC16A4 | 0.74 | 0.009 | 0.307 |
|
| |||
| S vs F (ER+HER2+) | |||
|
| |||
| HER2 | 1.79 | 0.058 | 0.875 |
| DUSP4 | 1.44 | 0.081 | 0.875 |
| RAB25 | 1.08 | 0.053 | 0.875 |
| L1CAM | 1.03 | 0.030 | 0.875 |
| GAB2 | 0.77 | 0.055 | 0.875 |
|
| |||
| PDX vs Original (ER+HER2−) | |||
|
| |||
| RAB25 | 2.24 | <0.001 | 0.036 |
| ACC (pS79) | 1.85 | <0.001 | 0.046 |
| S6 (pS240) | 1.69 | <0.001 | 0.036 |
| MYH9 | 1.54 | 0.012 | 0.138 |
| SLC1A5 | 1.41 | 0.018 | 0.166 |
|
| |||
| PDX vs Original (ER+HER2+) | |||
|
| |||
| AKT | 2.51 | <0.001 | 0.020 |
| S6 (pS235) | 2.50 | 0.004 | 0.094 |
| EGFR | 1.85 | 0.002 | 0.058 |
| 4E-BP1 (pT37) | 1.71 | 0.010 | 0.140 |
| MYH11 | 1.54 | 0.001 | 0.058 |