Table 4.

Top 5 of down regulated proteins in original patients tumors which were successfully engrafted into NSG mice (S) compared to tumors were not successfully engrafted (F), and in comparison between PDX tumors (PDX) and paired original patient tumors (Original)

S vs F (ER+HER2−)	LogFC	p-value	adj.p-value
ER	−1.74	0.022	0.398
MYH9	−1.36	0.016	0.398
GATA3	−1.13	0.031	0.451
AR	−1.08	0.025	0.398
ACC (pS79)	−0.87	0.056	0.563
S vs F (ER+HER2+)
CDH1	−1.21	0.119	0.875
SRC (pY527)	−0.86	0.049	0.875
RB1	−0.65	0.109	0.875
MAPK (pT202)	−0.63	0.111	0.875
MAP2K1	−0.54	0.095	0.875
PDX vs Original (ER+HER2−)
ROCK1	−2.05	<0.001	0.036
MYC	−1.70	0.002	0.063
SOD2	−1.59	0.007	0.136
HSP70	−1.54	0.008	0.136
COL6A1	−1.41	0.008	0.136
PDX vs Original (ER+HER2+)
HSP70	−1.75	0.005	0.094
ROCK1	−1.68	<0.001	0.020
AXL	−1.54	0.001	0.058
PREX1	−1.28	0.017	0.174
CNST43	−1.03	0.010	0.140