Table 1.

Summary of lncRNAs active in neural development

lncRNA	Tissue/Cell Line	Effect of knockdown/deletion	Protein binding partner	Refs
Cyrano	Zebrafish embryonic brain and notocord	Microcephaly, tail curling, neural tube defects, loss of NeuroD-positive neurons in zebrafish embryos treated with morpholino		[20]
Dali	N2A mouse neuroblastoma cell line	Decreased neurite growth and size during differentiation	POU3F3 DNMT1	[53]
Dlx1as	V-SVZ transit-amplifying cells and neuroblasts Embryonic interneuron progenitors	Decreased neurogenesis from VSVZ-NSCs. Increased DLX1 expression in adult mouse Dlx1as-depleted brains.		[22, 71]
Evf2	Embryonic interneuron progenitors	Decreased number of GABAergic interneurons in early postnatal hippocampus of Evf-2 depleted brains	DLX1 DLX2 BRG1 MECP2	[61–63, 72]
Linc-Brn1b	Cortical progenitors	Reduction of intermediate progenitors in the developing cortex. Reduced cortical layer II-IV thickness and barrel cortex disruption in knockout mice.		[60, 78]
Megamind/TUNA	mESCs and neural progenitors H9 human ESCs Mouse and zebrafish embryonic brain	Reduction of neural commitment of ESCs and neuronal differentiation Hydrocephalus and loss of NeuroD-positive neurons in zebrafish embryos treated with morpholino	PTBP1 HNRNP-K NCL	[20, 54]
Paupar	N2A mouse neuroblastoma cell line	Cell cycle arrest and increased neurite outgrowth upon differentiation.	PAX6	[52]
Pinky	V-SVZ NSCs Cortical progenitors	Increased production of neurons from V-SVZ NSCs and expansion of TA population. Increased production of neuroblasts and depletion of embryonic stem cell population.	PTBP1	[48]
RMST	H9-derived human neural stem cells	Decreased neuronal differentiation	SOX2 HNRNPA2/B1	[50]
Six3os	V-SVZ NSCs Retinal progenitor cells	Decreased generation of neurons and oligodendrocytes from V-SVZ-NSCS. Decreased production of rod bipolar cells and increase in production of Muller glia from retinal progenitors.	EZH2 EYA1 EYA3 EYA4	[22, 59]