Table 5.

Recommendation of immunohistochemistry profiles for the evaluation of bone marrow involvement of lymphoma

Diffuse large B cell lymphoma	CD3, CD20, CD5, CD10, BCL6, MUM-1 (presence of nodule:Ki-6y)
Follicular lymphoma	CD3, CD10, CD20, BCL6, MUM-1
Mantle cell lymphoma	CD3, CD5, CD20, CD79a, Cyclin D1
MALToma	CD3, CD79a, CD20, BCL6 (presence of nodule:Ki-67)
Burkitt lymphoma	Oil red O on aspiration smear CD10, CD20, BCL6, CD3 (presence of nodule:Ki-67)
Lymphoblastic lymphoma	CD3, CD5, TdT, CD20, PAX-5, CD34
Angioimmunoblastic T cell lymphoma	CD2, CD3, CD5, CD10, CD21, CD34
Peripheral T cell lymphoma	CD2, CD3, CD5, CD4, CD8, CD20, CD79a
Anaplastic large cell lymphoma	CD3, CD5, CD15, CD30, CD45, CD2, CD20, ALK-1
NK/T cell lymphoma	CD2+, CD56+, sCD3-, cCD3e+, CD4-, CD5-, CD8-, EBER+, granzyme+, TIA+

MALToma, mucosa-associated lymphoid tissue lymphoma; ALK, anaplastic lymphoma kinase; sCD3^–, surface CD3^–; cCD3e⁺, cytoplasmic CD3e⁺.