Table 2.
Cox-proportional hazard ratios for each variables by univariable and multivariable analysis
| Variable | Univariable | Multivariable |
||||||
|---|---|---|---|---|---|---|---|---|
| Anemia |
BMI |
PNI |
||||||
| HR (95% CI) | p value | aHR (95% CI) | p value | aHR (95% CI) | p value | aHR (95% CI) | p value | |
| PFS | ||||||||
| Anemia | 1.29 (1.05–1.58) | 0.015 | 1.17 (0.95–1.45) | 0.132 | - | - | - | - |
| 18.5 ≤ BMI < 25 | 1.36 (1.04–1.78) | 0.024 | - | - | 1.31 (1.00–1.71) | 0.047 | - | - |
| BMI < 18.5 | 1.98 (1.28–3.06) | 0.002 | - | - | 1.62 (1.04–2.52) | 0.033 | - | - |
| PNI < 45 | 1.57 (1.26–1.96) | < 0.001 | - | - | - | - | 1.48 (1.18–1.85) | 0.001 |
| Age at diagnosis | 0.98 (0.97–0.99) | < 0.001 | 0.98 (0.97–0.99) | < 0.001 | 0.98 (0.97–0.99) | < 0.001 | 0.98 (0.97–0.99) | < 0.001 |
| ECOG PS | 1.91 (1.47–2.49) | < 0.001 | 2.13 (1.63–2.78) | < 0.001 | 2.09 (1.60–2.74) | < 0.001 | 1.94 (1.47–2.55) | < 0.001 |
| TKI as 2nd line | 1.57 (1.27–1.94) | < 0.001 | 1.45 (1.17–1.80) | 0.001 | 1.51 (1.22–1.87) | < 0.001 | 1.51 (1.22–1.87) | < 0.001 |
| TKI as 3rd line | 2.24 (1.45–3.45) | < 0.001 | 2.30 (1.48–3.56) | < 0.001 | 2.25 (1.45–3.50) | < 0.001 | 2.38 (1.54–3.68) | < 0.001 |
| OS | ||||||||
| Anemia | 1.51 (1.19–1.93) | 0.001 | 1.31 (1.03–1.68) | 0.030 | - | - | - | - |
| 18.5 ≤ BMI < 25 | 1.27 (0.93–1.76) | 0.136 | - | - | 1.32 (0.97–1.81) | 0.080 | - | - |
| BMI < 18.5 | 2.52 (1.46–4.34) | 0.001 | - | - | 2.50 (1.43–4.37) | 0.001 | - | - |
| PNI < 45 | 1.90 (1.47–2.45) | < 0.001 | - | - | - | - | 1.97 (1.51–2.57) | < 0.001 |
| Age at diagnosis | 1.00 (0.99–1.01) | 0.669 | - | - | - | - | - | - |
| ECOG PS | 2.29 (1.67–3.16) | < 0.001 | 2.36 (1.71–3.26) | < 0.001 | 2.39 (1.73–3.30) | < 0.001 | 2.10 (1.51–2.91) | < 0.001 |
| TKI as 2nd line | 1.95 (1.51–2.53) | < 0.001 | 1.92 (1.48–2.49) | < 0.001 | 2.07 (1.60–2.69) | < 0.001 | 2.17 (1.67–2.82) | < 0.001 |
| TKI as 3rd line | 2.05 (1.17–3.60) | 0.013 | 2.32 (1.31–4.09) | 0.004 | 2.12 (1.19–3.77) | 0.011 | 2.37 (1.34–4.18) | 0.003 |
Hazard ratio was calculated using Cox-proportional hazard model. Anemia compared with non-anemic population; 25 ≤ BMI was compared to the 18.5 ≤ BMI < 25 and BMI < 18.5; 45 ≤ PNI were compared to PNI < 45; ECOG PS 0 & 1 were compared to ECOG PS 2, 3 & 4; Population with 1st line TKI treated group were compared to population with 2nd line and 3rd line TKI treated group. Age was analyzed in continuous variable.
HR, hazard ratio; CI, confidence interval; aHR, adjusted HR; PFS, progression free survival; BMI, body mass index; PNI, prognostic nutritional index; ECOG PS, Eastern Cooperative Oncology Group performance score; TKI, tyrosine kinase inhibitor; OS, overall survival.