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. 2016 May 21;7(24):35535–35551. doi: 10.18632/oncotarget.9550

Figure 6. Elevated expression of white adipose tissue (WAT) signature genes with aging is blunted in KO compared to WT mice.

Figure 6

Enrichment of WAT signature genes among genes with age-increased expression in A. WT and B. KO mice. Parts A. and B. show cumulative overlap of the 100 WAT signature genes relative to a list of genes ranked according to how strongly their expression is increased by aging (age-increased: left of vertical line; age-decreased: right of vertical line). Significant overlap of WAT signature genes and age-increased genes is indicated by a positive area between the cumulative overlap curve and diagonal. Similarly, C. and D. show cumulative overlap between WAT signature genes and genes ranked according to how strongly their expression is elevated in KO compared to WT mice (C: young mice; D: old mice; KO-increased: left of vertical line; KO-decreased: right of vertical line). Parts E. and F. list WAT signature genes and their FC estimates (old/young) in E. WT and F. KO mice. The 15 WAT signature genes with highest FC (WAT/liver) are listed.

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