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. 2016 May 21;7(24):35643–35654. doi: 10.18632/oncotarget.9543

Figure 1. Neddylation inhibitor MLN4924 attenuates DSS-induced colitis in mice.

Figure 1

A. MLN4924 prevented colon shortening in DSS-induced colitis. B. Weight loss curve for MLN4924 or cyclodextrin treated DSS mice. C. Clinical score represented colitis severity. D. Representative micrograph showed attenuated inflammation in MLN4924 treatment group compared with control group. Scale bar for 200μm. E.-F. MLN4924 reduced cytokine secretion measured by ELISA. Results were presented as the mean ± SEM. *p < .05, **p < .01, ***p < .001.