Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Neddylation inhibitor MLN4924 suppressed the conjugation of Nedd8 to Cullins and reduced SCF mediated polyubiquitination of Deptor for proteasomal degradation. The accumulation of Deptor inactivated mTOR signaling pathway, resulting in dendritic cell biological functions suppression.
