Table 3. Univariate and multivariate Cox proportional hazards regression analyses on the factors associated with overall survival in breast cancer.

Factors	Univariate			Multivariate
	HR	95% CI	P values	HR	95% CI	P values
Age	0.94	0.87–1.02	0.144	0.94	0.87–1.02	0.167
Tumor size	1.50	1.13–1.99	0.005	1.23	0.87–1.73	0.237
Lymph node stage (N0 vs. N1 vs. N2 vs. N3)	2.72	1.33–5.54	0.006	2.20	1.04–4.66	0.040
Nuclear grade (1 vs. 2 vs. 3)	2.79	1.13–6.92	0.027	2.25	0.93–5.42	0.071
SAA in tumor cell (− vs. +)	2.91	0.56–15.09	0.203	1.02	0.10–10.32	0.985
SAA+ macrophage (− vs. + vs. ++)	8.73	1.28–59.41	0.027	6.26	0.91–43.11	0.063
CD68+ macrophage (− vs. + vs. ++)	6.72	0.86–52.59	0.070	1.20	0.12–11.54	0.876

Note: SAA: serum amyloid A; vs.: versus. Lymph node stage: N0, indicates no lymph node metastasis; N1, 1–3 lymph node metastasis; N2, 4–9 lymph node metastasis; N3, ≥ 10 lymph node metastasis.