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. 2016 Apr 29;7(24):35894–35916. doi: 10.18632/oncotarget.9116

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Copyright: © 2016 Yang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Scheme 1 — The TMs and CD90@TMs was prepared to target and kill CD90⁺ LCSCs. It was demonstrated that CD90⁺ LCSCs could be effectively ablated by CD90@TMs. Magnetic hyperthermia-treated CD90⁺ LCSCs could cause a significant delay in tumor initiation in vivo tumor initiation study. CD90@TMs showed higher inhibition rate of tumor mass and tumor volume compared to TMs in hepatocarcinoma-bearing mice. Abbreviations: CD90, cluster of differentiation 90; PEG₂₀₀₀-DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol) -2000]; TMs, thermosensitive magnetoliposomes; LCSCs, live cancer stem cells; AMF, alternating magnetic field; MACS, magnetic-activated cell sorting.