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. 2016 Mar 24;7(24):35932–35945. doi: 10.18632/oncotarget.8321

Figure 2. The tumor gene set (TGS) identified in the 4-NQO model of oral tumorigenesis is relevant to human disease and discriminates oral squamous cell carcinoma (OSCC) from normal mucosa samples.

Figure 2

Hierarchical clustering and principal component analysis (PCA) using the TGS in: a set of 45 normal oral mucosa samples, 17 oral dysplasia, 167 OSCC (GSE30784) [22]. A. and a set of 12 normal tongue samples and 26 Oral Tongue SCC (OTSCC) (GSE9844) [21] B. Enrichment scores (ES) were computed for the TGS in GSE30784 C., GSE9844 (D), and in the TCGA set of 221 OSCC and 24 normal oral mucosa samples (E). Statistical significance was given by a Mann Whitney test D and E. or a Kruskal-Wallis test (C). We observed a significant difference (P<0.0001) between ES of normal, dysplastic and tumor samples in all datasets.