Table 2. Genotype frequencies of the SNP rs2718058 in total subjects stratified by ApoE ε4 status.
| rs2718058 | N | Genotypes (n %) | Alles (n %) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| A/A | A/G | G/G | P | A | G | P | OR (95% CI) | ||
| Total samples | |||||||||
| AD | 984 | 604 (61.4) | 318 (32.3) | 62 (6.3) | 0.181 | 1526 (77.5) | 442 (22.5) | 0.331 | 1.072 0.932~1.234 |
| Control | 1354 | 840 (62.0) | 452 (33.4) | 62 (4.6) | 2132 (78.4) | 576 (21.6) | |||
| ApoEε4 carriers | |||||||||
| AD | 280 | 190 (67.9) | 72 (25.7) | 18 (6.4) | 0.520 | 452 (80.7) | 108 (19.3) | 0.177 | 0.804 (0.585~1.104) |
| Control | 191 | 120 (62.8) | 56 (29.3) | 15 (7.9) | 296 (77.1) | 88 (22.9) | |||
| ApoEε4non-carriers | |||||||||
| AD | 704 | 414 (58.8) | 246 (35.0) | 44 (6.2) | 0.061 | 1074 (76.3) | 334 (23.7) | 0.052 | 1.170 0.999~1.371 |
| Control | 1163 | 720 62.0) | 396 (34.0) | 47 (4.0) | 1836 (79) | 488 (21) | |||
ApoEε4 carrier: Subjects who contain 1 or 2 ε4 alleles;
ApoEε4 non-carrier: Subjects who do not contain ε4allele.