Figure 5. Increasing levels of cytoplasmic Ca²⁺ induce cell death and c-Myc downregulation in MM cells.

(A) MM cell lines (NCI-H929, MM1S and U266) and PBMCs were exposed to different doses of A23817. The relative cell survival ratio was measured after 48 hours using the MTS assay. The data represent the mean ± SD of three independent experiments (**P < 0.01, Tukey–Kramer test). (B) Time-dependent effects of A23817 treatment (100 ng/ml) on c-Myc expression in NCI-H929 and MM1S cells, as analyzed by immunoblotting.