Skip to main content
. 2016 May 2;7(24):36101–36114. doi: 10.18632/oncotarget.9137

Figure 6. RET-fusion genes in cancer.

Figure 6

(Upper panel) Location of the RET oncogene and its fusion partner on chromosome 10. (Lower panel) Schematic summary of the RET fusion genes associated with RET-positive cancer. The CCDC6 gene product, also known as H4 (D10S170), TPC, or TST1, generates the oncogene RET/PTC1. RET/PTC3 is a fusion of RET and the activating NCOA4 gene (RFG/ELE1/PTC3/ARA70 gene). GOLGA5 (PTC5), generates the oncogene RET/PTC5, and TRIM33 (ECTO/PTC7/RFG7) generates the oncogene RET/PTC7. TRIM 24/27/33, tripartite motif-containing 24/27/33; ERC1, ELKS/RAB6-interacting/CAST family member 1; GOLGA5, golgin A5; HOOK3, hook microtubule-tethering protein 3; KTN1, kinectin 1; PCM1, pericentriolar material 1; PRKAR1A, protein kinase, cAMP-dependent regulatory type I alpha; AKAP13, A-kinase anchor proteins; FKBP15, FK506-binding protein; SPECC1L, sperm antigen with calponin homology And coiled-coil domains 1-like; TBL1XR1, transducin (beta)-like 1 X-linked receptor 1; BCR, breakpoint cluster region; FGFR1OP, FGFR1 oncogene partner.