Table 3. Subgroup analysis for OS and RFS according to PLT-PLR score.
| PLT-PLR | N (%) | OS, months | RFS, months | |||||
|---|---|---|---|---|---|---|---|---|
| Median (SD) | 95% CI | P | Median (SD) | 95% CI | P | |||
| Stage | ||||||||
| pI and pII | 0 | 89(53.9) | 61.014(3.377) | 54.395-67.632 | 0.002 | 53.384(3.619) | 46.291-60.477 | 0.003 |
| 1 | 67(40.6) | 51.197(4.062) | 43.236-59.158 | 43.905(4.290) | 35.497-52.313 | |||
| 2 | 9(5.5) | 27.695(9.395) | 9.282-46.108 | 18.370(8.079) | 2.535-34.205 | |||
| pIII | 0 | 19(51.4) | 37.717(18.733) | 1.001-74.433 | 0.221 | 11.663(4.451) | 2.939-20.388 | 0.724 |
| 1 | 12(32.4) | 38.500(17.175) | 4.837-72.163 | 12.057(5.620) | 1.042-23.073 | |||
| 2 | 6(16.2) | 9.166(3.106) | 3.078-15.255 | 6.505(2.286) | 2.024-10.986 | |||
| Age (yr) | ||||||||
| < 65 | 0 | 50(54.9) | 64.991(4.407) | 56.353-73.628 | 0.013 | 53.127(5.051) | 43.227-63.028 | 0.207 |
| 1 | 34(37.4) | 55.156(6.092) | 43.216-67.096 | 44.467(6.610) | 31.512-57.422 | |||
| 2 | 7(7.7) | 37.428(11.515) | 14.858-59.998 | 30.329(11.378) | 8.027-52.630 | |||
| ≥ 65 | 0 | 58(52.3) | 66.793(23.153) | 21.412-112.173 | < 0.001 | 40.214(18.758) | 3.449-76.980 | < 0.001 |
| 1 | 45(40.5) | 50.464(17.928) | 15.325-85.604 | 27.214(18.203) | 0.000-62.891 | |||
| 2 | 8(7.2) | 9.166(3.505) | 2.297-16.036 | 6.374(1.165) | 4.090-8.658 | |||
| Smoking | ||||||||
| Never smoker | 0 | 34(50.0) | 58.563(5.396) | 47.988-69.138 | 0.007 | 47.126(5.770) | 35.816-58.436 | 0.108 |
| 1 | 32(47.1) | 51.704(6.285) | 39.386-64.022 | 45.813(6.529) | 33.016-58.609 | |||
| 2 | 2(2.9) | 9.544(3.170) | 3.330-15.758 | 9.544(3.170) | 3.330-15.758 | |||
| Current or Ex-smoker | 0 | 74(55.2) | 58.121(3.960) | 50.359-65.884 | 0.002 | 49.736(4.190) | 41.524-57.948 | 0.002 |
| 1 | 47(35.1) | 50.277(4.826) | 40.818-59.736 | 40.399(5.081) | 30.441-50.356 | |||
| 2 | 13(9.7) | 29.472(8.539) | 12.737-46.208 | 19.524(6.987) | 5.830-33.218 | |||
| Sex | ||||||||
| Male | 0 | 88(52.1) | 55.027(3.673) | 47.829-62.226 | 0.002 | 47.102(3.833) | 39.589-54.615 | 0.002 |
| 1 | 67(39.6) | 49.096(4.189) | 40.885-57.307 | 41.603(4.378) | 33.023-50.184 | |||
| 2 | 14(8.3) | 27.212(8.136) | 11.265-43.159 | 18.658(6.545) | 5.829-31.486 | |||
| Female | 0 | 20(60.6) | 71.272(5.302) | 60.880-81.664 | 0.001 | 65.676(2.783) | 60.220-71.131 | 0.099 |
| 1 | 12(36.4) | 61.945(8.848) | 44.603-79.286 | 33.857 | ||||
| 2 | 1(3.0) | 16.953 | 11.696 | |||||
| Histology | ||||||||
| SqCC | 0 | 61(48.8) | 57.701(4.282) | 49.308-66.095 | < 0.001 | 50.523(4.510) | 41.684-59.362 | < 0.001 |
| 1 | 53(42.4) | 43.592(4.575) | 34.626-52.559 | 34.520(4.601) | 25.501-43.538 | |||
| 2 | 11(8.8) | 20.987(7.558) | 6.172-35.802 | 14.913(5.573) | 3.990-25.836 | |||
| Non-SqCC | 0 | 47(61.0) | 58.616(4.824) | 49.161-68.071 | 0.096 | 46.457(5.126) | 36.411-56.503 | 0.098 |
| 1 | 26(33.8) | 66.095(5.900) | 54.531-77.659 | 59.314(6.731) | 46.121-72.507 | |||
| 2 | 4(5.2) | 35.368(17.107) | 1.839-68.897 | 27.215(16.922) | 0.000-60.382 | |||
Abbreviations: PLT, platelet; PLR, platelet-to-lymphocyte ratio; SqCC, squamous cell carcinoma; Non-SqCC, non-squamous cell carcinoma