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. 2016 May 5;7(24):36207–36219. doi: 10.18632/oncotarget.9183

Figure 6. The up-regulation of miR-200b and miR-200c expression in the liver prevents hepatic lipid accumulation in mice fed a HFD.

Figure 6

Six-to-eight-week-old male C57BL/6J mice fed a HFD for 8 weeks were injected with Ad-200b, Ad-200c or Ad-con through the tail vein and sacrificed 7 days later. (A) Levels of hepatic miR-200b and miR-200c. (B, C) Body weight, liver weight and liver weight-to-body weight ratio. (D) H&E and Oil Red O staining of frozen liver sections. (E) Hepatic triglyceride content. (F) Western blots showing the hepatic expression of JUN, SREBP1 and FAS. The data represent the mean ± SEM, n = 6 mice. **P < 0.01 and ***P < 0.001 versus the control.