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. 2016 May 6;7(24):36293–36310. doi: 10.18632/oncotarget.9202

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Copyright: © 2016 Hsu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Identification of MYCN-regulated genes based on the overlap of MYCN-bound genes and MYCN-correlated genes. (B) Pie chart depicting the percentage of different classes of MYCN-regulated genes. (C, D) GO analysis of MYCN-activated (C) and MYCN-repressed (D) genes. (E) A hierarchical clustering graph representing the association between the expression of MYCN-regulated genes and MYCN, as well as risk status. Data from SEQC RNA-seq are represented as a Pearson correlation metric with average linkage. (F) Kaplan-Meier survival curves of MYCN-non-amplified NB patient groups defined by k-means clustering of expression of 874 MYCN-regulated genes. The graph depicts the p-value as obtained from the Log-rank test. Numbers in parentheses are the number of patients in each group.