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A group of genes repressed by MYCN and MYCN-regulated microRNAs has been reported as tumor suppressor candidates in NB and other cancer types. The RNA binding proteins SYNCRIP and IGF2BP3 are up-regulated by MYCN and might bind to MYCN or MYCN-regulated genes to maintain their mRNA stability. Orange and green nodes represent the MYCN-activated and -repressed genes, respectively.
