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. 2016 Apr 27;7(24):36510–36528. doi: 10.18632/oncotarget.9058

Figure 10. Expression levels of CDK5 and related markers in renal biopsies of DN patients and relationship with renal fibrosis.

Figure 10

A. Immunohistochemical staining of CDK5, p35, phosphorylated ERK1/2 and PPARγ, E-cadherin, Vimentin and Collagen IV in ES-DN (n=49), LS-DN (n=37) and NC (n=5). B. Quantification of the staining intensity compared between groups. C. Deteriorated TIF in LS-DN compared with ES-DN and NC by MTS and D. interstitial injury score compared between groups. Results are presented as mean ± SD of three independent experiments. *P<0.05, #P<0.001. NC, normal controls; ES-DN, early staged diabetic nephropathy; LS-DN, late staged diabetic nephropathy; TIF, tubulointersitial fibrosis; MTS, Masson's trichrome stain.