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. 2016 Apr 27;7(24):36510–36528. doi: 10.18632/oncotarget.9058

Figure 5. U0126 inhibits PPARγ-mediated EMT in high glucose cultured NRK-52E cells.

Figure 5

A. Effect of U0126 on the expression of phosphorylated ERK1/2 and PPARγ, E-cadherin, Vimentin and Collagen IV compared between conditions. B. Decreased phosphorylated ERK1/2 (red) and phosphorylated PPARγ (green) with U0126 treatment in high glucose condition (30 mM). C. Increased E-cadherin but decreased Vimentin and Collagen IV expression with U0126 treatment. D. Decreased migrated cells with U0126 treatment. E. Decreased invaded distance with U0126 treatment. Results are presented as mean ± SD of three independent experiments. *P<0.05, #P<0.001 compared with DMSO. Inline graphic, DMSO; Inline graphic, U0126.