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. 2016 Apr 27;7(24):36510–36528. doi: 10.18632/oncotarget.9058

Figure 6. Roscovitine inhibits EMT via ERK1/2/PPARγ pathway in high glucose cultured NRK-52E cells.

Figure 6

A. Decreased phosphorylated ERK1/2 (red) and PPARγ (green) with roscovitine treatment. B, C. Roscovitine downregulated phosphorylated ERK1/2 and PPARγ with increased E-cadherin but decreased Vimentin and Collagen IV. D. Decreased migrated cells with roscovitine. E. Decreased invaded distance with roscovitine. F. P35 attenuates the inhibitory effect of U0126 on the expression of phosphorylated ERK1/2 and PPARγ, E-cadherin, Vimentin and Collagen IV. Results are presented as mean ± SD of three independent experiments. *P<0.05, #P<0.001 compared with DMSO. Ros., Roscovitine. Inline graphic, DMSO; Inline graphic, Ros.