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. 2016 Apr 27;7(24):36510–36528. doi: 10.18632/oncotarget.9058

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Copyright: © 2016 Bai et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. Decreased CDK5 (green) and phosphorylated ERK1/2 (red) with CDK5 siRNA. B, C. CDK5 siRNA increased E-cadherin but decreased phosphorylated ERK1/2 and PPARγ, Vimentin and Collagen IV. D. Decreased migrated cells with CDK5 siRNA. E. Decreased invaded distance with CDK5 siRNA. Results are presented as mean ± SD of three independent experiments. *P<0.05, #P<0.001 compared with NT siRNA. EMT, epithelial-to-mesenchymal transition. , NT siRNA; , CDK siRNA.

Inline graphic — A. Decreased CDK5 (green) and phosphorylated ERK1/2 (red) with CDK5 siRNA. B, C. CDK5 siRNA increased E-cadherin but decreased phosphorylated ERK1/2 and PPARγ, Vimentin and Collagen IV. D. Decreased migrated cells with CDK5 siRNA. E. Decreased invaded distance with CDK5 siRNA. Results are presented as mean ± SD of three independent experiments. *P<0.05, #P<0.001 compared with NT siRNA. EMT, epithelial-to-mesenchymal transition. , NT siRNA; , CDK siRNA.