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. 2016 Apr 27;7(24):36510–36528. doi: 10.18632/oncotarget.9058

Figure 8. Effect of roscovitine on diabetic rats and controls.

Figure 8

A. Immunohistochemical staining of CDK5, p35, phosphorylated ERK and PPARγ, E-cadherin, Vimentin and Collagen IV indiabetic rats and controls with or without roscovitine treatment. B. Quantification of the staining intensity compared between groups. C. Representative images of MTS in diabetic rats and controls and D. interstitial injury score compared between groups. Results are presented as mean ± SD for groups of 6-9 rats of three independent experiments. *P<0.05, #P<0.001. NC-D, normal control rats treated with dimethyl sulphoxide; NC-R, normal control rats treated with roscovitine; DM-D, diabetic rats treated with dimethyl sulphoxide; DM-R, diabetic rats treated with roscovitine; MTS, Masson's trichrome stain.