Skip to main content
. 2016 May 4;7(24):36767–36782. doi: 10.18632/oncotarget.9168

Table 1. DCP antagonizes Sorafenib-mediated inhibition of HCC tumor growth HLE xenograft-bearing nude mice.

Groups Number of mice (n) Body weight (g)a (initial/21 days) Tumor weightb (g, mean ± SD) Tumor growth inhibition (%)
Vehicle 6 18.3 ± 1.1/21.2 ± 1.2 1.03 ± 0.26 -
Sorafenib 25 mg/kg 6 18.5 ± 1.4/20.5 ± 1.6 0.52 ± 0.22** 49.3
DCP 40 μg/kg 6 18.3 ± 1.3/21.8 ± 1.4 1.29 ± 0.29* −25.2
Sorafenib + DCP 6 18.6 ± 0.9/20.4 ± 1.7 0.98 ± 0.21 4.8

Established xenografts were treated with Sorafenib by gavage, DCP by intravenous injection or Sorafenib plus DCP. All treatments were performed five times per week for three weeks in total.

a

Body weight was measured as indicated over time.

b

Tumors were measured after mice were sacrificed.

*

p < 0.05

**

p < 0.01 vs. the vehicle control.