Table 1. DCP antagonizes Sorafenib-mediated inhibition of HCC tumor growth HLE xenograft-bearing nude mice.
Groups | Number of mice (n) | Body weight (g)a (initial/21 days) | Tumor weightb (g, mean ± SD) | Tumor growth inhibition (%) |
---|---|---|---|---|
Vehicle | 6 | 18.3 ± 1.1/21.2 ± 1.2 | 1.03 ± 0.26 | - |
Sorafenib 25 mg/kg | 6 | 18.5 ± 1.4/20.5 ± 1.6 | 0.52 ± 0.22** | 49.3 |
DCP 40 μg/kg | 6 | 18.3 ± 1.3/21.8 ± 1.4 | 1.29 ± 0.29* | −25.2 |
Sorafenib + DCP | 6 | 18.6 ± 0.9/20.4 ± 1.7 | 0.98 ± 0.21 | 4.8 |
Established xenografts were treated with Sorafenib by gavage, DCP by intravenous injection or Sorafenib plus DCP. All treatments were performed five times per week for three weeks in total.
Body weight was measured as indicated over time.
Tumors were measured after mice were sacrificed.
p < 0.05
p < 0.01 vs. the vehicle control.