Figure 6. Androgen/AR axis promotes oncogenesis of HCC cells in vivo.

A. Nanog^Pos and Nanog^Neg cells from T1224+1 and Huh7+7 were subcutaneously implanted in male nude mice. Animals were derived as groups of control (no treated), castrated or castrated supplemented with testosterone propionate (TP). The tumor volume was measured and presented as mean ± SD of 6 mice per group. P<0.05(*), p<0.01(**) and p<0.001(***). B. Immunohistochemistry staining of AR and Nanog in continuous sections from subcutaneous transplantation tumor derived from Huh7+7 cells. Scale bars, 100μm.