Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
JWA enhances PEA3 expression and its negative transcriptional activity on the HER2 promoter by activating MEK/ERK, resulting in HER2 downregulation. A decreased HER2 level, which attenuates HER2 downstream PI3K/AKT signaling, Rac1/Cdc42 activation, PAK1 activation and F-actin-based pseudopod stretching, represses cell motility in HER2-positive gastric cancer cells.
