Table 2. Cox regression analyses of JWA, HER2 and clinicopathologic variables for overall survival in the advanced gastric cancer (n=128).
| Variables | P | HR | 95% CI | |
|---|---|---|---|---|
| Lower | Upper | |||
| Univariate analysis | ||||
| Age (years)(>57 vs ≤57) | 0.539 | 1.134 | 0.760 | 1.692 |
| Gender(Males vs Females) | 0.194 | 1.316 | 0.870 | 1.990 |
| Disease status(Metastatic vs Local advanced) | 0.417 | 1.258 | 0.723 | 2.188 |
| Depth of invasion(T3/T4 vs T1/T2) | 0.656 | 1.134 | 0.652 | 1.973 |
| Tumor diameter(cm)(>5 vs ≤5) | 0.861 | 0.961 | 0.614 | 1.503 |
| Primary Location (GEJ vs Mid to distal stomach) | 0.704 | 0.924 | 0.613 | 1.392 |
| Histologic type(Diffuse/mixed vs Intestinal) | <0.001 | 2.793 | 1.818 | 4.291 |
| Grading(G3 vs G1/G2) | 0.134 | 1.359 | 0.909 | 2.030 |
| Lymph node metastasis(N2/N3 vs N0/N1) | 0.001 | 2.107 | 1.355 | 3.278 |
| Peritoneum metastasis(positive vs negative) | <0.001 | 2.894 | 1.745 | 4.800 |
| Liver metastasis(positive vs negative) | <0.001 | 2.104 | 1.392 | 3.178 |
| Number of metastasis organs(>1 vs 1) | 0.097 | 1.466 | 0.933 | 2.303 |
| Performance status (ECOG)(2 vs 0-1) | <0.001 | 2.606 | 1.718 | 3.953 |
| Previous gastrectomy(Yes or No) | 0.404 | 1.200 | 0.782 | 1.841 |
| Chemotherapy agents(Triplet vs Doublet/Single) | 0.092 | 0.654 | 0.399 | 1.072 |
| HER2 expression(high vs low) | 0.119 | 1.448 | 0.909 | 2.306 |
| JWA expression(low vs high) | <0.001 | 2.463 | 1.597 | 3.788 |
| JWA/HER2 expression | ||||
| (JWA high HER2 low vs. both low or high) | <0.001 | 0.281 | 0.153 | 0.516 |
| (JWA high HER2 low vs JWA low HER2 high) | 0.009 | 0.457 | 0.253 | 0.824 |
| Multivariate analysis | ||||
| JWA | ||||
| Performance status (ECOG)(2 vs 0-1) | <0.001 | 2.257 | 1.431 | 3.558 |
| Histologic type(Diffuse/mixed vs Intestinal) | 0.002 | 2.033 | 1.291 | 3.202 |
| Lymph node metastasis(N2/N3 vs N0/N1) | 0.030 | 1.722 | 1.053 | 2.816 |
| Peritoneum metastasis(positive vs negative) | 0.001 | 2.527 | 1.463 | 4.365 |
| Liver metastasis(positive vs negative) | 0.153 | 1.413 | 0.880 | 2.268 |
| JWA expression(low vs high) | 0.024 | 1.773 | 1.079 | 2.915 |
| JWA/HER2 | ||||
| Performance status (ECOG)(2 vs 0-1) | 0.003 | 2.081 | 1.289 | 3.360 |
| Histologic type(Diffuse/mixed vs Intestinal) | <0.001 | 2.774 | 1.667 | 4.614 |
| Lymph node metastasis(N2/N3 vs N0/N1) | 0.051 | 1.670 | 0.998 | 2.794 |
| Peritoneum metastasis(positive vs negative) | 0.002 | 2.425 | 1.386 | 4.244 |
| Liver metastasis(positive vs negative) | 0.405 | 1.241 | 0.746 | 2.065 |
| JWA/HER2 expression | ||||
| (JWA high HER2 low vs. both low or high) | 0.024 | 2.262 | 1.112 | 4.608 |
| (JWA low HER2 high vs JWA high HER2 low) | 0.006 | 3.096 | 1.395 | 6.897 |
GEJ, Gastroesophageal junction; ECOG, Eastern Cooperative Oncology Group; HR, hazard ratio; CI, confidence interval.