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. 2016 May 6;7(24):36896–36908. doi: 10.18632/oncotarget.9213

Figure 3. CCL5 promotes VEGF-C-dependent lymphangiogenesis by suppressing miR-507.

Figure 3

The JJ012/vector, JJ012/shCCL5, JJ012/CCL5, SW1353/vector, SW1353/shCCL5 and SW1353/CCL5 cells cultured for 24 h, and miR-507 expression was examined by qPCR A. In addition, cells were transfected with miR-507 mimic or inhibitor for 24 h, and VEGF-C expression was examined by qPCR B. ELISA C. and Western blot E. (n = 5-7). The medium was collected as CM and then applied to LECs for tube formation assay D. (n = 5). Results are expressed as the mean ± SE. *, p < 0.05 compared with JJ012 control; #, p < 0.05 compared with SW1353 control; †, p < 0.05 compared with CCL5-knockdowned group; ‡, p < 0.05 compared with CCL5-overexpressed group.