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. 2016 May 15;7(24):36909–36923. doi: 10.18632/oncotarget.9377

Figure 3. Ectopic expression of miR-129-2 ameliorates HCC migration and invasion, both in vitro and in vivo.

Figure 3

(A) The expression of miR-129-2 was significantly increased in Hep3B and Huh7 cells infected with miR-129-2 expression or control lentiviruses. Cell migration as measured by wound healing assay (B) and Transwell migration assay (C) was inhibited by up-regulation of miR-129-2 in Hep3B and Huh7 cells as compared with control cells. n = 6 repeats with similar results. (D) MiR-129-2 over-expressing Hep3B and Huh7 cells conferred a lower number of invaded cells as compared with control cells. n = 6 repeats with similar results.(E) Upregulated miR-129-2 had no obvious difference on cell proliferation, as determined by MTT. (F) Representative hematoxylin and eosin (H&E) images of metastatic nodules from the mouse lung and liver tissue sections (left) of the Huh7-miR-control group and the Huh7-miR-129-2 group. The number of metastatic nodules in the lungs of each group was presented as the mean SD (right). Experiments were repeated at least 6 times with similar results, and error bars represent ± SD. *P < 0.05, **P < 0.01.