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. 2016 May 15;7(24):36909–36923. doi: 10.18632/oncotarget.9377

Figure 7. miR-129-2 selectively inhibits AKT phosphorylation at Ser473.

Figure 7

(A) The total expression of AKT (t-AKT) and phosphorylation levels of AKT, including p-AKT (Ser473) and p-AKT (Thr308), were analyzed by Western blot. (B) The major upstream regulators of p-AKT (Thr308) were probed by Western blot. (C) Left Panel: the representative picture of immunochemical staining of serial HCC sections for p-AKT (Ser473) and MMP2/9 sections in the different miR-129-2 expression levels tissues. Right Panel: the correlation of miR-129-2 level with those of p-AKT (Ser473) and MMP2/9 in 106 HCC patients. Correlation between two variables was calculated bySpearman rank correlation coefficient. n = 6 independent experiments. *P < 0.05, **P < 0.01.