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. 2016 May 9;7(24):36971–36987. doi: 10.18632/oncotarget.9235

Figure 8. Graphical representation of the proposed model and public data integration.

Figure 8

A. The proposed model of regulation regarding the cleaved fragment of Par-4. (B-D) Data from two independent dataset taken from a study from Prentzel et al. (PMID 21862633). Relative Par-4 mRNA expression was used in all cases. B. The use of Bortezomib, a potent proteasome inhibitor, significantly increases Par-4 expression in MCF7 cells while estradiol significantly reduces it. However, the use of both reverse the negative effect of estradiol (GEO accession GDS4089). C. The use of estradiol in MCF7 cells significantly reduces Par-4 expression and Bortezomib treatment reverse this effect (GEO accession GDS4090). D. The knockdown of PSMB3 and PSMB5 (Proteasome subunits) induces a significant increase of Par-4 mRNA in MCF7 cells (GEO accession GDS4090). Results are mean ± S.E.M. of three independent experiments and P<0.05.