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. 2016 May 18;7(24):37013–37029. doi: 10.18632/oncotarget.9455

Figure 7. The anti-HER3 antibody 9F7-F11 induces JNK1/2 phosphorylation leading to ITCH activation in cancer cells.

Figure 7

Serum-starved cells from BxPC3 (A) and DU145 (B) cell lines were incubated with 100 ng/mL NRG-1β and/or 50 μg/mL 9F7-F11 for the indicated times. JNK1/2 and ITCH protein expression and their phosphorylation status were assessed in whole cell extracts by western blotting using the appropriate antibodies. Band signal intensity (SI) was quantified with ImageJ and β-actin was used as loading control.