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. 2016 May 9;7(24):37064–37080. doi: 10.18632/oncotarget.9245

Figure 1. Prostate cancer develops uniformly in the TRAMP mouse model.

Figure 1

A. Progressive cancer burden in TRAMP mice monitored by the cumulative weight of the genitourinary (GU) tract (includes prostate, seminal vesicles, testicles and empty urinary bladder). GU tracts were weighed from both wild type and TRAMP mice at the indicated ages (6-22 weeks) and normalised to respective mouse body weights (n=5-15 at each age). Horizontal black lines represent the mean GU tract weight at the indicated age. B. Representative photographs of harvested GU tracts from wild type and TRAMP mice at 10, 18 and 22 weeks of age. C. Histological examination of prostate lobes [anterior prostate (AP), dorsolateral prostate (DLP) and ventral prostate (VP)] with hematoxylin and eosin (H&E) staining, verifying disease grade in TRAMP mice at the indicated ages (6-22 weeks) (n=5 at each age). The most advanced proliferative lesion in each lobe signified the grade of disease. D. Representative H&E-stained sections displaying grades of prostate disease in TRAMP mice from hyperplasia, low-grade PIN, high-grade PIN, adenocarcinoma and invasive adenocarcinoma. H&E-stained normal prostate was obtained from wild type mice. (***p < 0.001).