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. 2016 May 9;7(24):37064–37080. doi: 10.18632/oncotarget.9245

Figure 5. Altered systemic copper distribution impedes prostate cancer growth in TRAMP mice.

Figure 5

A. The tx mutation significantly reduces prostate cancer burden in TRAMP mice. Genitourinary (GU) tracts were weighed from 22-week old and 26-week old wild type, tx, TRAMP and tx/TRAMP mice and normalised to respective mouse body weights (n=5-15 for each strain). The mean ± STDEV (whisker plot) for each strain is shown. B. The tx mutation significantly reduces prostate cancer disease severity (grade) in TRAMP mice. Histological examination of prostate lobes [anterior prostate, dorsolateral prostate and ventral prostate] with hematoxylin and eosin (H&E) staining, establishing disease grade in 26-week old wild type, tx, TRAMP and tx/TRAMP mice (n=5 for each strain). The most advanced proliferative lesion in each lobe signified the grade of disease. C. Representative H&E-stained sections displaying prostate disease grade in the prostate lobes [anterior prostate (AP), dorsolateral prostate (DLP) and ventral prostate (VP)] of 26-week old TRAMP and tx/TRAMP mice. (*p < 0.05; **p < 0.01; ***p < 0.001)