Table 3. Associations between methylation status and H. pylori infection in gastric mucosa in Stage II case-control validation.
| H. pylori negative n (%) | H. pylori positive n (%) | P value | ORa | 95% CIa | |
|---|---|---|---|---|---|
| SPI1 (cut-off value 89.9%) | |||||
| Hypermethylated | 12 (48.0) | 2 (8.0) | 0.018 | 0.12 | 0.02–0.70 |
| Hypomethylated | 13 (52.0) | 23 (92.0) | |||
| PRIC285 (cut-off value 79.5%) | |||||
| Hypermethylated | 12 (48.0) | 5 (20.0) | 0.238 | 0.41 | 0.09–1.81 |
| Hypomethylated | 13 (52.0) | 17 (68.0) | |||
| Missing | 3 (12.0) | ||||
| S1PR4 (cut-off value 80.3%) | |||||
| Hypermethylated | 13 (52.0) | 3 (12.0) | 0.021 | 0.15 | 0.03–0.75 |
| Hypomethylated | 10 (40.0) | 20 (80.0) | |||
| Missing | 2 (8.0) | 2 (8.0) | |||
| CELSR3 (cut-off value 0%) | |||||
| Methylated | 8 (32.0) | 9 (36.0) | 0.969 | 0.97 | 0.24–3.97 |
| Unmethylated | 15 (60.0) | 14 (56.0) | |||
| Missing | 2 (8.0) | 2 (8.0) | |||
a
Unconditional logistic regression analysis, adjusted for age, sex, smoking, drinking and pathologic diagnosis.