Table 2. Delivery and toxicity of mTPF (median number of cycles: 4; total number of cycles: 214).

Toxicities	First cycle (n = 48)	Second cycle (n = 44)	Third cycle (n = 38)	Fourth cycle (n = 27)
Febrile neutropenia	2 (4%)	0	1 (3%)	1 (4%)
Diarrhea (gr 3-4)	3 (6%)	1 (2%)	1 (3%)	0
Secondary hospitalization	5 (10%)	4 (9%)	2 (5%)	3 (8%)
Transient creatinine elevation	4 (8%)	5 (11%)	2 (5%)	2 (5%)
Cause of discontinuation	4 interruptions for toxicity (8%)	1 death (2%) 4 interruptions for toxicity (8%)	1 death (3%) 2 interruptions for toxicity (5%)	Planned. No toxicity