Table 3.
Functional outcome comparison
| Variable | RRP (N = 97) | HDR (N = 161) | Cryo (N = 114) | HIFU (N = 120) | P value |
|---|---|---|---|---|---|
| Urethral stricture, N (%) | 29 (29.9) | 10 (6.2) | 4 (3.3) | 13 (10.8) | 0.000 |
| Secondary TURP or OIU, N (%) | 28 (28.9) | 18 (11.2) | 10 (8.8) | 16 (13.3) | 0.000 |
| Urinary incontinence, N (%) | 11 (11.3) | 1 (0.6) | 2 (1.6) | 3 (2.5) | 0.000 |
| Epididymitis, N (%) | 2 (2.1) | 6 (3.7) | 8 (7.3) | 7 (5.8) | 0.311 |
| Scrotal edema, N (%) | 0 (0.0) | 0 (0.0) | 85 (74.7) | 0 (0.0) | 0.000 |
| Rectal injury, N (%) | 1 (1.0) | 3 (1.9) | 0 (0.0) | 0 (0.0) | 0.243 |
| Irradiation cystitis, N (%) | 0 (0.0) | 6 (3.7) | 0 (0.0) | 0 (0.0) | 0.006 |
| Irradiation proctitis, N (%) | 0 (0.0) | 7 (4.3) | 0 (0.0) | 0 (0.0) | 0.002 |
| Erectile dysfunction at 12 months, N (%)a | 32/38 (84.2) | 30/34 (88.2) | 44/50 (88.0) | 21/32 (65.6) | 0.042 |
| IIEF-5 at 6 months (mean ± SD)a | 6.08 ± 6.27 | 4.85 ± 5.52 | 4.02 ± 5.95 | 8.55 ± 8.41 | 0.031 |
| IIEF-5 at 12 months (mean ± SD)a | 6.33 ± 6.06 | 4.81 ± 5.47 | 3.61 ± 5.21 | 9.67 ± 7.74 | 0.003 |
| IIEF-5 at 18 months (mean ± SD)a | 6.74 ± 6.07 | 4.79 ± 5.32 | 4.50 ± 5.96 | 10.16 ± 8.11 | 0.008 |
| IIEF-5 at 24 months (mean ± SD)a | 5.48 ± 5.28 | 4.76 ± 5.48 | 4.18 ± 5.89 | 9.36 ± 6.33 | 0.067 |
| IPSS at 6 months (mean ± SD) | 9.55 ± 6.11 | 7.51 ± 5.81 | 10.43 ± 6.50 | 7.26 ± 4.41 | 0.009 |
| IPSS at 12 months (mean ± SD) | 9.69 ± 6.01 | 7.48 ± 5.56 | 9.54 ± 5.87 | 6.25 ± 3.42 | 0.021 |
| IPSS at 18 months (mean ± SD) | 9.52 ± 6.05 | 7.49 ± 5.67 | 9.15 ± 6.08 | 5.82 ± 3.75 | 0.047 |
| IPSS at 24 months (mean ± SD) | 9.31 ± 5.83 | 7.50 ± 5.43 | 9.04 ± 6.30 | 5.70 ± 3.53 | 0.184 |
| QoL at 6 months (mean ± SD) | 2.50 ± 1.59 | 2.27 ± 1.33 | 2.75 ± 1.41 | 1.90 ± 0.14 | 0.017 |
| QoL at 12 months (mean ± SD) | 2.52 ± 1.57 | 2.30 ± 1.42 | 2.59 ± 1.42 | 1.83 ± 1.01 | 0.097 |
| QoL at 18 months (mean ± SD) | 2.45 ± 1.56 | 2.32 ± 1.28 | 2.5 ± 1.41 | 1.86 ± 1.17 | 0.318 |
| QoL at 24 months (mean ± SD) | 2.50 ± 1.65 | 2.33 ± 1.47 | 2.47 ± 1.40 | 1.98 ± 1.4 | 0.794 |
RRP radical retropubic prostatectomy, HDR high dose rate brachytherapy, Cryo cryoablation, HIFU high-intensity focused ultrasound, TURP transurethral resection of the prostate, OIU optic internal urethrotomy, SD standard deviation, IIEF-5 5-item version of the international index of erectile function, IPSS international prostate symptom score, QoL quality of life
aErectile dysfunction and Mean scores for IIEF-5 were restricted to those men who reported IIEF-5 ≥ 17 at baseline