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. 2016 Nov 4;7:479. doi: 10.3389/fimmu.2016.00479

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Copyright © 2016 Hasegawa, Mizoguchi, Chiba, Ohashi, Xu and Yoshimoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-30 and its related molecules. IL-6 is unique in signaling through not only membrane-bound IL-6Rα but also sIL-6Rα. The former is called IL-6 classic signaling through membrane-bound IL-6Rα together with gp130, and the latter is called IL-6 trans-signaling by IL-6 bound with sIL-6Rα and IL-6/sIL-6Rα (also designated Hyper-IL-6) through only gp130. The α subunit of IL-27, p28, which is referred to as IL-30, functions as an agonistic cytokine via the gp130 signaling pathway similar to IL-6, either by itself or associating with other molecules such as IL-12p40, CLF, IL-6Rα, forming p28/IL-6Rα classic signaling, p28/sIL-6Rα trans-signaling, and p28 signaling. Moreover, p28 can activate signal transduction via gp130, even in the absence of IL-6Rα or EBI3, albeit at higher concentrations.