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. 2016 Nov 4;7:481. doi: 10.3389/fphys.2016.00481

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Copyright © 2016 Senatore, Raiss and Le.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maximum likelihood protein phylogeny of select Ca_v channels from animals, rooted with Ca_v channel homologs from fungi. Inference was achieved using MUSCLE protein alignment with MEGA7, followed by alignment trimming with TrimAL. Evolutionary models for maximum likelihood phylogenetic inference were tested with MEGA7, indicating that the LG matrix with gamma frequencies was the best fit using both corrected Akaike's Information Criterion and Bayesian Information Criterion. Node support values from 500 bootstrap replicates are indicated. GenBank accession numbers: Salpingoeca Ca_v1/Ca_v2: XP_004989719; Amphimedon Ca_v1/Ca_v2: XP_003383036; Trichoplax Ca_v1: XP_002108930; Trichoplax Ca_v2: XP_002109775; Trichoplax Ca_v3: KJ466205; C.elegans Ca_v1 (egl-19): NP_001023079; C.elegans Ca_v2 (unc-2): NP_001123176; C.elegans Ca_v3 (cca-1): CCD68017; Drosophila Ca_v1 (α1-D): AAF53504; Drosophila Ca_v2 (cacophony): AFH07350; Drosophila Ca_v3 (Ca-α1T): ABW09342; Lymnaea Ca_v1: AAO83839; Lymnaea Ca_v2: AAO83841; Lymnaea Ca_v3: AAO83843; human Ca_v1.1: NP_000060.2; human Ca_v1.2: AAI46847.1; human Ca_v1.3: NP_001122312.1; human Ca_v1.4: NP_005174.2; human Ca_v2.1: O00555.2; human Ca_v2.2: NP_000709; human Ca_v2.3: NP_001192222.1; human Ca_v3.1: NP_061496; human Ca_v3.2: NP_066921; human Ca_v3.3: NP_066919; Mnemiopsis Ca_v2: AEF59085; S.cerevisae CCH1: P50077; S.pombe CCH1: NP_593894.1. Other accession numbers: Nematostella Ca_v1: JGI-Genome Portal protein ID 88037; Nematostella Ca_v2a, Ca_v2b, Ca_v2c, Ca_v3a, Ca_v3b: Transcript sequences from the sequenced transcriptome (Fredman et al., 2013) NVE4667, NVE18768, NVE1263, NVE5017, and NVE7616 respectively. Scale bar represents the number of amino acid substitutions per site along the sequence alignment.