Table 2.
Clinical and pathological characteristics of patients with locally advanced rectal cancer
| Variables | All patients n = 364 (%) |
BMI loss <7 % n = 325 (%) |
BMI loss ≥7 % n = 39 (%) |
P value |
|---|---|---|---|---|
| Clinical variables | ||||
| Age, median (range) | 56 (15–80) | 55 (15–80) | 62 (33–76) | 0.007 |
| Gender (male: female) | 259:115 | 224:101 | 25:14 | 0.54 |
| Mean preCRT BMI (kg/m2) | 22.5 ± 3.1 | 22.4 ± 3.1 | 22.6 ± 2.9 | 0.72 |
| Mean inferior tumor margin from anal verge, cm (SD) | 4.9 ± 2.2 | 4.9 ± 2.1 | 5.2 ± 2.7 | 0.35 |
| cT stage | 0.46 | |||
| 3 | 216 (59.3) | 195 (60.0) | 21 (53.8) | |
| 4 | 148 (40.7) | 130 (40.0) | 18 (46.2) | |
| cTNM stage | 0.12 | |||
| II | 127 (34.9) | 109 (33.5) | 18 (46.2) | |
| III | 237 (65.1) | 216 (66.5) | 21 (53.8) | |
| Pathological variables | ||||
| Mean size of tumor after CRT, cm (SD) | 3.0 ± 1.6 | 3.0 ± 1.5 | 3.4 ± 1.9 | 0.14 |
| Tumor differentiation | 0.90 | |||
| Well and moderate | 283 (77.7) | 253 (77.8) | 30 (76.9) | |
| Poor | 81 (22.3) | 72 (22.2) | 9 (23.1) | |
| Median number of lymph nodes examined (range) | 6 (0–37) | 6 (0–37) | 6 (0–21) | 0.99 |
| Median number of positive lymph nodes (range) | 0 (0–12) | 0 (0–12) | 0 (0–4) | 0.42 |
| ypT stage | 0.42 | |||
| 0–2 | 181 (49.7) | 164 (50.5) | 17 (43.6) | |
| 3–4 | 183 (50.3) | 161 (49.5) | 22 (56.4) | |
| ypN stage | 0.50 | |||
| 0 | 283 (77.7) | 251 (77.2) | 32 (82.1) | |
| 1–2 | 81 (22.3) | 74 (22.8) | 7 (17.9) | |
| ypTNM stage | 0.87 | |||
| 0 | 85 (23.4) | 76 (23.4) | 9 (23.1) | |
| I | 77 (21.2) | 69 (21.2) | 8 (20.5) | |
| II | 121 (33.2) | 106 (32.6) | 15 (38.5) | |
| III | 81 (22.2) | 74 (22.8) | 7 (17.9) | |
| Achievement of pCR | 0.97 | |||
| Yes | 85 (23.4) | 76 (23.4) | 9 (23.1) | |
| No | 279 (76.6) | 249 (76.6) | 30 (76.9) | |
BMI body mass index, SD standard deviation, cTNM stage clinical tumor-node-metastasis classification, cT stage clinical tumor stage, ypT stage pathologic tumor stage after chemoradiotherapy, ypN stage pathologic node stage after chemoradiotherapy, ypTNM stage pathologic tumor-node-metastasis classification after chemoradiotherapy, pCR pathologic complete response