Table 4.

Treatment-related adverse events during preoperative chemoradiotherapy in patients with locally advanced rectal cancer

Toxicity	BMI loss <7 % n = 235 (%)	BMI loss ≥7 % n = 39 (%)	P value	Toxicity	BMI loss <7 % n = 235 (%)	BMI loss ≥7 % n = 39 (%)	P value
Leucopenia				Rash
Total	190 (58.5)	26 (66.7)	0.33	Total	40 (12.3)	3 (7.7)	0.40
Grade 1–2	176 (54.2)	25 (64.1)	0.24	Grade 1–2	36 (11.1)	1 (2.6)	0.13
Grade 3–4	14 (4.3)	1 (2.6)	0.61	Grade 3–4	4 (1.2)	2 (5.1)	0.10
Thrombocytopenia				Urination disorder
Total	72 (22.2)	9 (23.1)	0.90	Total	10 (3.1)	1 (2.6)	0.86
Grade 1–2	62 (19.1)	9 (23.1)	0.55	Grade 1–2	10 (3.1)	1 (2.6)	0.86
Grade 3–4	10 (3.1)	0	1	Grade 3–4	0	0
Nausea/vomiting				Renal disorder
Total	150 (46.2)	19 (48.7)	0.76	Total	2 (0.6)	2 (5.1)	0.033
Grade 1–2	149 (45.8)	19 (48.7)	0.73	Grade 1–2	2 (0.6)	2 (5.1)	0.033
Grade 3–4	1 (0.3)	0	1	Grade 3–4	0	0
Diarrhea				Hepatic disorder
Total	102 (31.4)	19 (48.7)	0.033	Total	44 (13.5)	7 (17.9)	0.46
Grade 1–2	91 (28.0)	16 (41.0)	0.09	Grade 1–2	42 (12.9)	7 (17.9)	0.39
Grade 3–4	11 (3.4)	3 (7.7)	0.20	Grade 3–4	2 (0.6)	0	1
Hand-foot syndrome				Neurotoxicity
Total	225 (69.2)	27 (69.2)	1	Total	53 (16.3)	5 (12.8)	0.58
Grade 1–2	216 (66.5)	25 (64.1)	0.77	Grade 1–2	53 (16.3)	5 (12.8)	0.58
Grade 3–4	9 (2.8)	2 (5.1)	0.42	Grade 3–4	0	0
Radiation proctitis
Total	198 (60.9)	24 (61.5)	0.94
Grade 1–2	192 (59.1)	21 (53.8)	0.53
Grade 3–4	6 (1.8)	3 (7.7)	0.041

BMI body mass index