Table 5.
Univariate and multivariate analysis of risk factors for overall survival in the patients with locally advanced rectal cancer
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95 % CI) | P value | HR (95 % CI) | P value | |
| Age >60 year | 1.360 (0.856–2.162) | 0.19 | ||
| Gender (female) | 1.139 (0.702–1.847) | 0.60 | ||
| PreCRT BMI ≤18.5 kg/m2 | 1.248 (0.640–2.436) | 0.52 | ||
| PreCRT weight ≤50 kg | 1.430 (0.784–2.607) | 0.24 | ||
| cT stage 4 | 1.439 (0.867–2.387) | 0.16 | ||
| cTNM stage III | 1.269 (0.734–2.193) | 0.39 | ||
| DAV ≤ 5 cm | 1.158 (0.947–1.417) | 0.15 | ||
| Tumor size ≥3 cm | 1.158 (0.701–1.915) | 0.57 | ||
| Histopathology (poor grade) | 1.175 (0.689–2.002) | 0.55 | ||
| Number of retrieved LNs ≥12 | 0.776 (0.456–1.322) | 0.35 | ||
| ypT stage 3–4 | 2.411 (1.462–3.976) | 0.001 | 1.781 (1.054–3.010) | 0.031 |
| ypN stage 1–2 | 3.227 (2.031–5.126) | <0.001 | 2.571 (1.576–4.192) | <0.001 |
| Preoperative CRT with oxaliplatin | 0.466 (0.202–1.075) | 0.07 | ||
| Completed dose of preoperative chemotherapy >50 % | 0.470 (0.253–0.874) | 0.017 | 0.532 (0.284–0.997) | 0.049 |
| Radiotherapy completion | 0.627 (0.195–2.015) | 0.43 | ||
| Anterior resection | 0.694 (0.438–1.100) | 0.12 | ||
| Acceptance of postoperative chemotherapy | 0.798 (0.457–1.393) | 0.43 | ||
| Duration of postoperative chemotherapy ≥12 weeks | 0.843 (0.489–1.453) | 0.45 | ||
| BMI loss ≥7 % during preoperative CRT | 1.961 (1.055–3.647) | 0.030 | 1.984 (1.061–3.709) | 0.032 |
BMI body mass index, HR hazard ratio, CI confidence interval, DAV distance of inferior tumor margin from the anal verge, cT stage clinical tumor stage, cTNM stage clinical tumor-node-metastasis classification, LNs lymphonodus, ypT stage pathologic tumor stage after chemoradiotherapy, ypN stage pathologic node stage after chemoradiotherapy, CRT chemoradiotherapy