Table 3.
Stratified Analyses for the Associations Between Standardized FT4 and the Risk of All Stroke and Fatal Strokea
| All Strokeb |
I2 | Fatal Strokec |
I2 | |||||
|---|---|---|---|---|---|---|---|---|
| Events/Total Participants, n | Age- and Sex-Adjusted HR (95% CI) | Multivariable HR (95% CI)d | Events/Total Participants, n | Age- and Sex-Adjusted HR (95% CI) | Multivariable HR (95% CI)d | |||
| Total population FT4 per SD | 1307/24 888 | 1.08 (0.99, 1.17) | 1.06 (0.99, 1.15) | 55% | 598/32 580 | 1.10 (1.04, 1,19) | 1.09 (1.02, 1.18) | 0% |
| Sexe | ||||||||
| Men | 639/11 848 | 1.02 (0.94, 1.11) | 1.00 (0.92, 1.08) | 0% | 284/16 651 | 1.10 (0.99, 1.24) | 1.08 (0.96, 1.21) | 0% |
| Women | 668/13 040 | 1.10 (0.99, 1.22) | 1.10 (1.01, 1.20) | 52% | 314/15 929 | 1.12 (1.03, 1.23) | 1.12 (1.01, 1.24) | 0% |
| P for interaction | .27 | .12 | .79 | .65 | ||||
| Age, yf | ||||||||
| 18–49 | 59/8289 | 0.81 (0.61, 1.07) | 0.75 (0.55, 1.03) | 0% | 12/9507 | 1.50 (0.62, 3.67) | 0.93 (0.32, 2.71) | 36% |
| 50–64 | 342/9019 | 1.03 (0.93, 1.29) | 1.03 (0.84, 1.27) | 66% | 99/11 929 | 1.09 (0.88, 1.35) | 1.06 (0.84, 1.32) | 0% |
| 65–79 | 759/6803 | 1.12 (1.05, 1.19) | 1.10 (1.04, 1.17) | 0% | 376/9897 | 1.11 (1.01, 1.22) | 1.09 (0.99, 1.21) | 0% |
| ≥80 | 147/777 | 1.15 (0.98, 1.35) | 1.15 (0.96, 1.38) | 0% | 111/1247 | 1.12 (0.94, 1.33) | 1.09 (0.89, 1.33) | 0% |
| P for trend | .024 | .015 | .54 | .76 | ||||
| Stroke historyg | ||||||||
| No | 1013/22 446 | 1.06 (0.95, 1.18) | 1.05 (0.95, 1.15) | 58% | 472/27 256 | 1.10 (1.02, 1.19) | 1.09 (1.00, 1.18) | 0% |
| Yes | 104/483 | 1.11 (0.95, 1.29) | 1.12 (0.95, 1.32) | 0% | 60/668 | 1.07 (0.78, 1.45) | 1.15 (0.77, 1.73) | 26% |
| P for interaction | .64 | .51 | .87 | .80 | ||||
| Stroke typeh | ||||||||
| Hemorrhagic | 17/1577 | 1.37 (0.82–2.29) | 1.15 (0.64–2.07) | NA | 10/1577 | 1.15 (0.63–2.12) | 1.01 (0.49, 2.07) | NA |
| Ischemic | 157/1577 | 1.30 (1.14–1.47) | 1.20 (1.06–1.37) | NA | 39/1577 | 1.00 (0.71–1.41) | 0.90 (0.62–1.28) | NA |
| P for interaction | .84 | .88 | .70 | .77 | ||||
| Racei | ||||||||
| White | 617/10 208 | 1.12 (0.99, 1.26) | 1.11 (0.99 1.23) | 51% | 319/14 528 | 1.13 (1.03, 1.23) | 1.10 (1.00 1.21) | 0% |
| Asian | NA | NA | NA | NA | 63/3228 | 1.27 (0.74, 2.18) | 1.27 (0.74, 2.18) | 58% |
| Black | NA | NA | NA | NA | 2/48 | 0.94 (0.23, 3.88) | 1.00 (0.14, 7.09) | NA |
| P for interaction | NA | NA | .89 | .87 | ||||
Abbreviation: NA, not applicable. The HRs are per one increase in SD of FT4.
The Whickham Survey did not measure FT4 but total T4.
Data were available from 12 studies, and 384 participants were excluded due to missing stroke event data.
Twenty-seven participants were excluded due to missing data on cause of death.
Adjusted for sex, age, systolic BP, total cholesterol, smoking, and prevalent diabetes at baseline.
These analyses were not adjusted for sex.
These HRs were adjusted for sex and age as continuous variable to avoid residual confounding within age strata.
Information on stroke history was not available for the Pisa cohort, Birmingham Study, and Busselton Health Study. Data on stroke history were missing for 64 subjects.
Information on type of stroke was available for the Rotterdam Study.
Information on race was not available for the 4D study, Busselton Health Study, and EPIC-Norfolk Study. Ninety-six participants from the Osteoporotic Fractures in Men Study were excluded due to no events in subgroup.