Table 2.

Univariate and Multivariate Analyses of Potential Factors Associated With PFS

Parameter	Univariate Analysis			Multivariate Analysisa
	HRb	95% CI	P Valueb	HR	95% CI	P Valuea,b
Age (≤ vs > 65 y)	0.79	0.54–1.17	.24
Sex (male vs female)	1.26	0.86–1.84	.24
Baseline body weight (< vs ≥ median)	1.59	1.08–2.33	.02	1.55	1.03–2.32	004
Baseline ECOG performance status (< vs ≥ 1)	0.50	0.34–0.74	<.01	0.63	0.41–0.96	.03
Histology (follicular vs papillary)	0.64	0.43–0.97	.04	0.69	0.45–1.07	.10
Prior VEGF-targeted therapy (0 vs 1)	0.75	0.49–1.14	.18	0.86	0.55–1.34	.49
Baseline tumor size (< vs ≥ median)	0.49	0.33–0.72	<.01	0.61	0.40–0.94	.03
Percentage tumor reduction, wk 8 (< vs ≥ median)	1.67	1.11–2.50	.01	1.49	0.98–2.26	.06

^aMultivariate analysis includes only factors with P < .2 from univariate analyses.

^bHRs and P values were estimated with Cox proportional hazard models.